Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objective is to determine the maximum tolerated dose (MTD).
| Version: | 3.4.0 |
| Depends: | R (≥ 3.0.2), Rcpp (≥ 0.12.11), rstan (≥ 2.12.1) |
| Imports: | ggplot2 (≥ 2.0.0), dfcrm, methods, stats, graphics, grDevices, PK |
| LinkingTo: | StanHeaders (≥ 2.12.0), rstan (≥ 2.12.1), BH (≥ 1.60), Rcpp (≥ 0.12.0), RcppEigen |
| Published: | 2017-10-24 |
| Author: | Artemis Toumazi, Moreno Ursino and Sarah Zohar |
| Maintainer: | Artemis Toumazi <artemis.toumazi at inserm.fr> |
| BugReports: | http://github.com/artemis-toumazi/dfpk/issues |
| License: | GPL (≥ 3) | file LICENSE |
| Copyright: | stanmodels.R is copyright 2015, 2016 Trustees of Columbia University. All other files are copyright French National Institute of Health and Medical Research. |
| URL: | http://github.com/artemis-toumazi/dfpk |
| NeedsCompilation: | yes |
| SystemRequirements: | C++11 |
| Materials: | README |
| In views: | ClinicalTrials, ExperimentalDesign, Pharmacokinetics |
| CRAN checks: | dfpk results |
| Reference manual: | dfpk.pdf |
| Package source: | dfpk_3.4.0.tar.gz |
| Windows binaries: | r-devel: dfpk_3.4.0.zip, r-release: dfpk_3.4.0.zip, r-oldrel: dfpk_3.4.0.zip |
| OS X El Capitan binaries: | r-release: dfpk_3.4.0.tgz |
| OS X Mavericks binaries: | r-oldrel: dfpk_3.4.0.tgz |
| Old sources: | dfpk archive |
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